The Schroeder lab at UT Southwestern is hiring a postdoctoral fellow to study divergent cytoskeletal proteins that are mis-expressed in cancer.
Cytoskeletal proteins perform many fundamental roles, including cell motility, cargo transport and cell division. Given their essentiality, cytoskeletal proteins are conventionally thought to be conserved throughout eukaryotic evolution, yet we have found many cytoskeletal genes are rapidly evolving even between closely related species and adapted novel biological functions. We recently showed a few play important roles in fertility and development in flies, and a subset of these proteins in humans are mis-expressed in cancer. Although there are many divergent cytoskeletal proteins across phyla, they have been largely ignored most likely due to their lack of deep evolutionary roots. We combine evolutionary analyses, cell biology, genetics and biochemistry to understand the causes and consequences of cytoskeletal diversification and their impacts in fertility, development and cancer. Please see https://www.theschroederlab.org for more information.
Most divergent cytoskeletal proteins we find in mammals are testis-specific in expression with unexplored functions. A subset of these proteins in humans have significant gene amplifications and mutations in a number of cancers, and their expression consistently correlates with reduced survival time. The candidate will use evolutionary analyses, cell biology, genetics and biochemistry to understand how cytoskeletal diversification in the male germline is exploited in cancer and test how these proteins may endow cancerous cells with increased proliferative and migratory activity.
The candidate will benefit from the diverse and scientifically creative environment at UT Southwestern and can take advantage of the many cutting-edge core facilities offered, including live cell imaging, electron microscopy, and high throughput screening.
The ideal candidate values honesty, persistence, scientific curiosity, and a diverse lab environment. Candidates must have a PhD (received or forthcoming) in molecular biology, cell biology, biochemistry, or a related field and have an interest in the cytoskeleton and cancer. The proposed project entails tissue culture work and a minimal amount of work with mice. Although some experience with tissue culture and mice is preferred, it is not required. The candidate will be encouraged to apply for independent funding.
Please email Courtney Schroeder (CourtneyM.Schroeder@utsouthwestern.edu) the following:
1. Cover letter describing your interest in the position
3. Most important publication(s) from your PhD work
4. Contact info for 3 references
Deadline: Dec. 20